Ketamine was first synthesized by Parke Davis in 1962, and since then has been used millions of times as a surgical anesthetic. Dr. Grindle has over thirty years of experience administering it to patients in the operating room. It is one of only two anesthetics listed on the World Health Organization’s (WHO) Essential Drug List. It has an excellent safety profile as it does not depress breathing and the circulatory system, is fast-acting, and has minimal long-term side effects. Ketamine has also been found to be effective in treating several chronic pain syndromes. Most recently, ketamine has been discovered to be dramatically effective in in alleviating severe depression and suicidality in patients who have not found relief with traditional anti-depressants, as well as several anxiety disorders such as PTSD. Many experts are calling ketamine the most significant advance in mental health in more than half a century. For more information see articles.