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Inside the Los Angeles Clinic That Uses Ketamine to Treat Depression

Depression is all too common, especially among people in the tech sector. That’s why denizens of Silicon Beach have been flocking to a local clinic that offers a radical alternative when standard treatments fall short.

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FDA Data Support Ketamine as Depression Therapy

An analysis of data from the FDA Adverse Events Reporting System (FAERS) supported previous findings that ketamine could be an effective treatment for depression, researchers found.

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Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications

Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Adverse Effect Reporting System. The results of the examination of population scale data revealed that patients who received ketamine had significantly lower frequency of reports of depression than patients who took any other combination of drugs for pain. The analysis also revealed that patients who took ketamine had significantly lower frequency of reports of pain and opioid induced side effects, implying ketamine’s potential to act as a beneficial adjunct agent in pain management pharmacotherapy. Further, the Inverse-Frequency Analysis methodology provides robust statistical support for the antidepressant action of other currently approved therapeutics including diclofenac and minocycline.

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Analysis of print news media framing of ketamine treatment in the United States and Canada from 2000 to 2015

There are multifaceted views on the use of ketamine, a potentially addictive substance, to treat mental health problems. The past 15 years have seen growing media coverage of ketamine for medical and other purposes. This study examined the print news media coverage of medical and other uses of ketamine in North America to determine orientations and trends over time.

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Is ketamine the best hope for curing major depression?

On the seventh floor of a building overlooking the Federal Reserve Bank in lower Manhattan, two medical clinics share an office. One is run by a podiatrist who’s outfitted the waiting room with educational materials on foot problems such as hammer toes and bunions. The other clinic doesn’t have pamphlets on display and offers a much less conventional service: For the advertised price of $525, severely depressed and suicidal patients can get a 45-minute intravenous infusion of ketamine—better known as the illicit party drug Special K.

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The secret life of ketamine

It rains for 164 days out of each year in Portland, Oregon, a city renowned for its wet weather. So it seems an unlikely destination for patients hoping to alleviate their depression. Yet, over the past two years, almost a hundred people have visited a small nondescript clinic in this damp corner of Northwestern United States to receive ketamine, an experimental treatment for depression that can work where other drugs have failed.

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